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This could be due to the suppressed antioxidant capacity of NahG tobacco including glutathione levels 50% of wild type (Kirly et al., 2002

A 2024 systematic review concluded that "clinical data were limited, and in-human safety remains unknown." The majority of supportive data comes from animal models

and (3) increased Nrf2 levels in lung tissues to prevent ubiquitination or deubiquitination of Nrf2, thereby facilitating its nuclear translocation and inhibiting ferroptosis